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1-MNA
1-MNA
1-MNA
1-MNA
1-MNA
1-MNA
Description

1-MNA or ‘1-methylnicotinamide’ is a unique supplement that helps block the enzyme NNMT, supporting metabolic, brain, and cellular health by optimizing NAD levels. It is a natural compound produced in the body through the breakdown of niacin, a form of vitamin B3.

1-MNA has been shown to inhibit the enzyme NNMT, which when present in high levels, is associated with various diseases. By inhibiting this enzyme, 1-MNA can contribute to overall cellular health and disease prevention.

Researched extensively for its safety profile, 1-MNA supplementation aims to safely restore NAD levels, optimize cellular redox pathways, and combat age-related diseases comprehensively. As a natural byproduct of vitamin B3, 1-MNA also shows anti-inflammatory effects and supports vascular and cardiovascular health, making it a strong candidate for daily use.

  • Safely increase NAD levels and block NNMT
  • Renowned for its anti-inflammatory and anti-thrombotic qualities
  • Improve cell energy metabolism
  • Positive effect on Vascular Endothelium
  • Lowers levels of inflammatory markers


Benefits
  • Essential for maintaining vascular endothelial function and stimulating synthesis of prostacyclin (PGI2)
  • Bolsters the secretory function of the vascular endothelium, thereby safeguarding against dysfunction
  • Minimizes the risk of blood clot formation and inflammation via PGI2 synthesis.
  • Enhances the stability of sirtuins (Sirt1), which in certain biological models has been associated with extended lifespan
  • Considered a groundbreaking molecule with potent anti-inflammatory and anti-atherosclerotic effects
  • Leading research institutions suggest 1-MNA may extend human lifespan
  • Elevated levels of 1-MNA during exercise and fasting suggest that its consumption, particularly during endurance training, could enhance exercise capacity and improve performance


Ingredients

1-MNA (1-methylnicotinamide chloride) 58mg

Other Ingredients: cellulose, hydroxypropyl methyl cellulose, silicon dioxide.

Each bottle contains 30 capsules 58mg/capsule. Recommended daily dosage is one per day.


Dosage Recommendation

For health maintenance and longevity in younger or lower-risk patients: 1–2 capsules (58mg each) daily after a meal. For patients with more significant metabolic, cardiovascular, or inflammatory burden, or elderly patients: 3–5 capsules daily. 1-MNA has been safety-tested at up to 6 grams for 14 weeks and is a homeostatic substance — it works with the cell, not against it. Suggested 1-MNA Dosing Protocol 

Longevity Launch Labs

1-MNA

Regular price $89.00

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Endotelio 1-MNA is a unique supplement that helps block the enzyme NNMT, supporting metabolic, brain, and cellular health by optimizing NAD levels. As a natural byproduct of vitamin B3, 1-MNA also shows anti-inflammatory effects and supports vascular and cardiovascular health.
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Description

1-MNA or ‘1-methylnicotinamide’ is a unique supplement that helps block the enzyme NNMT, supporting metabolic, brain, and cellular health by optimizing NAD levels. It is a natural compound produced in the body through the breakdown of niacin, a form of vitamin B3.

1-MNA has been shown to inhibit the enzyme NNMT, which when present in high levels, is associated with various diseases. By inhibiting this enzyme, 1-MNA can contribute to overall cellular health and disease prevention.

Researched extensively for its safety profile, 1-MNA supplementation aims to safely restore NAD levels, optimize cellular redox pathways, and combat age-related diseases comprehensively. As a natural byproduct of vitamin B3, 1-MNA also shows anti-inflammatory effects and supports vascular and cardiovascular health, making it a strong candidate for daily use.

  • Safely increase NAD levels and block NNMT
  • Renowned for its anti-inflammatory and anti-thrombotic qualities
  • Improve cell energy metabolism
  • Positive effect on Vascular Endothelium
  • Lowers levels of inflammatory markers


Benefits
  • Essential for maintaining vascular endothelial function and stimulating synthesis of prostacyclin (PGI2)
  • Bolsters the secretory function of the vascular endothelium, thereby safeguarding against dysfunction
  • Minimizes the risk of blood clot formation and inflammation via PGI2 synthesis.
  • Enhances the stability of sirtuins (Sirt1), which in certain biological models has been associated with extended lifespan
  • Considered a groundbreaking molecule with potent anti-inflammatory and anti-atherosclerotic effects
  • Leading research institutions suggest 1-MNA may extend human lifespan
  • Elevated levels of 1-MNA during exercise and fasting suggest that its consumption, particularly during endurance training, could enhance exercise capacity and improve performance


Ingredients

1-MNA (1-methylnicotinamide chloride) 58mg

Other Ingredients: cellulose, hydroxypropyl methyl cellulose, silicon dioxide.

Each bottle contains 30 capsules 58mg/capsule. Recommended daily dosage is one per day.


Dosage Recommendation

For health maintenance and longevity in younger or lower-risk patients: 1–2 capsules (58mg each) daily after a meal. For patients with more significant metabolic, cardiovascular, or inflammatory burden, or elderly patients: 3–5 capsules daily. 1-MNA has been safety-tested at up to 6 grams for 14 weeks and is a homeostatic substance — it works with the cell, not against it. Suggested 1-MNA Dosing Protocol 

Recommended by 250+ US Clinicians

30+ Academic Led Scientific Studies

20+ Years of Research & Innovation

Internationally Recognized Patents

Why Patients Love 1-MNA (and Why It's Essential for NAD+ Protection)

1-MNA acts as a cellular guardian that protects and preserves your NAD+ investment. By blocking the NNMT enzyme that breaks down NAD+, 1-MNA ensures your body keeps more of the NAD+ it needs for optimal cellular function - giving you maximum return on every dose.

What patients experience with this protective partnership:
✅ More energy and better endurance
✅ Reduced inflammation and improved circulation
✅ Faster recovery and stronger performance
✅ Support for healthy aging and longevity

Think of 1-MNA as the shield that ensures NAD+ is working healthily in your system. While NAD+ powers your cellular engines, 1-MNA prevents that power from being wasted - creating a synergistic duo that maximizes your body's natural energy, repair, and longevity processes - making them the ultimate cellular duo.

Suggested Dosing Protocol

Increase NAD, the Safe Way.

1-MNA, short for 1-methylnicotinamide, is a natural compound produced in the body through the breakdown of niacin, a form of vitamin B3.

The molecule works at the cellular level to help balance key molecular pathways involved in NAD regulation and energy, endothelial function, oxidative stress, and longevity.

With multiple patents supporting the novel application of this molecule in supporting a healthy lifestyle, 1-MNA offers an opportunity to address cell health at the deepest level.

Suggested Dosing Protocol

The Only 1-MNA Product on the Market

1-MNA plays a crucial role in regulating NAD metabolism in the body, blocking the enzyme Nicotinamide N-methyltransferase (NNMT), which is a key regulator of the delicate redox balance, thereby restoring cellular health and optimizing NAD levels.

Endotelio's 1-MNA is a high-quality dietary supplement, synthesized through a unique technology developed in collaboration with European universities, manufactured in a GMP-certified facility in Eastern Europe, and has been recognized with awards for its groundbreaking contribution to cellular health.

1-MNA has been recognized for its anti-inflammatory and anti-thrombotic properties, along with its unique ability to improve cell energy metabolism.

Your Highest-Priority Patient Profiles

*in no particular order*

Patients with atherosclerosis, high triglycerides, coronary artery disease, elevated homocysteine, or a family history of heart disease. 1-MNA's well-documented vasoprotective and anti-thrombotic properties — including its ability to increase nitric oxide and prostacyclin — make it a natural fit here.

Patients with insulin resistance, obesity, high adipose tissue concentration, or a high-fat dietary pattern. 1-MNA has been shown to reduce triglycerides and LDL, support hepatic insulin sensitivity via SIRT1, and act as a fasting mimetic by stimulating lipolysis.

Patients with MTHFR variants or known methylation issues. Because NNMT steals methyl groups from SAMe — the universal methyl donor — overactive NNMT directly raises homocysteine. 1-MNA restores proper methylation balance in a way no B-vitamin protocol alone can.

Particularly those with long-COVID. A published clinical study demonstrated meaningful improvement in exercise tolerance and fatigue scores in post-COVID patients supplementing with 1-MNA.

Those who are already precursor or im/iv NAD+ users. This is your most important clinical conversation — and possibly the most nuanced. These patients deserve to know about the 4PY risk data, and they will respect you enormously for having it.
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